Genome location: Pf3D7_07_v3:1,235,416..1,236,794(+)
Genome classification: Core
Product Description: signal recognition particle subunit SRP9
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Component | GO:0005634 | nucleus |
| Component | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting |
| Function | GO:0005515 | protein binding |
| Function | GO:0043022 | ribosome binding |
| Process | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.27 | 0.87 |
| Trophozoite | expressed | 0.36 | 0.77 |
| Schizont | expressed | 0.12 | 0.92 |
| Gametocyte | expressed | 0.32 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0729000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.425 | MFS: -2.541 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4Q0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104467
Most Similar Human Ortholog: Q659G3
TM-align score: 0.83 | RMSD: 1.32
Seq Identity: 0.25 | Length: 52 / 103
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000143742 | signal recognition particle 9 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 5 | 1 | 3 |
| disruptive | 1 | 13 | 4 | 12 |
| missense | 1 | 13 | 4 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 10 | 1 | 4 |
| disruptive | 5 | 27 | 9 | 36 |
| missense | 2 | 24 | 6 | 25 |
PlasmoDB Total SNPs: 67
Non-coding: 64 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 103 | Molecular Weight (kDa): 12.135
PDB ID(s): None
Isoelectric Point: 10.1
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009018 | Signal recognition particle, SRP9/SRP14 subunit |
| InterPro | IPR039914 | Signal recognition particle SRP9/Srp21 |
| PFam | N/A | N/A |
| Superfamily | SSF54762 | Signal recognition particle, SRP9/SRP14 subunit |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 17919451 | Unraveling the components of protein translocation pathway in human malariaparasite Plasmodium falciparum. | Tuteja R | 10.1016/j.abb.2007.08.031 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24434517 | Plasmodium falciparum signal recognition particle components and anti-parasiticeffect of ivermectin in blocking nucleo-cytoplasmic shuttling of SRP. | Panchal M, Rawat K, ..., Tuteja R | 10.1038/cddis.2013.521 |
| 34017052 | Structural analysis of the SRP Alu domain from Plasmodium falciparum reveals anon-canonical open conformation | Soni K, Kempf G, ..., Sinning I | 10.1038/s42003-021-02132-y |
| 30664217 | Scutellaria barbata polysaccharides inhibit tumor growth and affect the serumproteomic profiling of hepatoma H22_bearing mice | Li L, Xu X, ..., Song G | 10.3892/mmr.2019.9862 |