Genome location: Pf3D7_07_v3:1,237,998..1,246,671(+)
Genome classification: Core
Product Description: apicomplexan kinetochore protein 8, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.5.3.4 (Allantoicase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000776 | kinetochore |
| Component | GO:0005634 | nucleus |
| Function | GO:0004037 | allantoicase activity |
| Process | GO:0000256 | allantoin catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.29 | 0.87 |
| Trophozoite | not expressed | 1.42 | 0.37 |
| Schizont | possibly expressed | 0.73 | 0.66 |
| Gametocyte | not expressed | 1.49 | 0.31 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0729100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.994 | MFS: -1.51 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1304400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0213200)
Modification: Tagged | RMgm-5120
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4Q1
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.5.3.4 | allantoicase | EDTANH4+phosphateAllantoateiodoacetateL-asparagineglycolic acidHydantoic acidN-Acetylimidazolediethyldicarbonate(-)-ureidoglycolatep-hydroxymercuribenzoate... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105441
Most Similar Human Ortholog: Q8N6M5
TM-align score: 0.78 | RMSD: 3.78
Seq Identity: 0.26 | Length: 362 / 2580
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000151360 | allantoicase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 110 | 60 | 137 |
| disruptive | 108 | 397 | 218 | 511 |
| missense | 59 | 327 | 193 | 426 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 30 | 229 | 90 | 154 |
| disruptive | 186 | 843 | 334 | 757 |
| missense | 112 | 675 | 276 | 509 |
PlasmoDB Total SNPs: 390
Non-coding: 69 | Synonymous: 147 | Nonsynonymous: 169 | Stop Codon: 5
Protein Length: 2580 | Molecular Weight (kDa): 304.521
UniProt ID(s): C0H4Q1
PDB ID(s): None
Isoelectric Point: 4.89
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005164 | Allantoicase |
| InterPro | IPR008979 | Galactose-binding-like domain superfamily |
| InterPro | IPR015908 | Allantoicase domain |
| PFam | PF03561 | Allantoicase domain |
| Superfamily | SSF49785 | Galactose-binding-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 36006241 | Composition and organization of kinetochores show plasticity in apicomplexanchromosome segregation | Brusini L, Dos Santos Pacheco N, ..., Brochet M | 10.1083/jcb.202111084 |