PF3D7_0729300 (NMD3)

Genome location: Pf3D7_07_v3:1,248,478..1,251,901(-)

Genome classification: Core

Function and Localization

Product Description: 60S ribosomal export protein NMD3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005634	nucleus
Function	GO:0043023	ribosomal large subunit binding
Process	GO:0000027	ribosomal large subunit assembly
Process	GO:0042273	ribosomal large subunit biogenesis
Process	GO:0000055	ribosomal large subunit export from nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.35	0.45
Trophozoite	expressed	1.00	0.51
Schizont	expressed	0.20	0.89
Gametocyte	expressed	0.58	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0729300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -2.946 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBG6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101748

Most Similar Human Ortholog: C9J0B9

TM-align score: 0.81 | RMSD: 2.74

Seq Identity: 0.36 | Length: 208 / 888

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000169251	NMD3 ribosome export adaptor

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	58	30	69
disruptive	16	110	53	112
missense	16	108	52	105

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	92	36	61
disruptive	38	202	88	200
missense	31	186	79	149

PlasmoDB Total SNPs: 155

Non-coding: 94 | Synonymous: 42 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 888 | Molecular Weight (kDa): 104.165

UniProt ID(s): Q8IBG6

PDB ID(s): None

Isoelectric Point: 6.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007064	Nmd3, N-terminal
InterPro	IPR039768	Ribosomal export protein Nmd3
PFam	PF04981	Nmd3, N-terminal
Superfamily	N/A	N/A