Product Description: ribosome biogenesis protein BRX1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005730 | nucleolus |
Component | GO:0005634 | nucleus |
Component | GO:0030687 | preribosome, large subunit precursor |
Process | GO:0000027 | ribosomal large subunit assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.54 | 0.74 |
Trophozoite | expressed | 0.33 | 0.81 |
Schizont | expressed | 0.06 | 0.96 |
Gametocyte | expressed | 0.30 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0729400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.865 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0213500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBG5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101913
Most Similar Human Ortholog: Q8TDN6
TM-align score: 0.62 | RMSD: 2.79
Seq Identity: 0.37 | Length: 241 / 416
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000113460 | biogenesis of ribosomes BRX1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 4 | 22 | 12 | 21 |
disruptive | 24 | 64 | 26 | 64 |
missense | 9 | 46 | 14 | 45 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 5 | 42 | 15 | 14 |
disruptive | 32 | 109 | 37 | 88 |
missense | 14 | 73 | 27 | 58 |
PlasmoDB Total SNPs: 216
Non-coding: 74 | Synonymous: 30 | Nonsynonymous: 112 | Stop Codon: 0
Protein Length: 416 | Molecular Weight (kDa): 49.531
UniProt ID(s): Q8IBG5
PDB ID(s): None
Isoelectric Point: 4.08
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR007109 | Brix domain |
InterPro | IPR026532 | Ribosome biogenesis protein BRX1 |
PFam | PF04427 | Brix domain |
Superfamily | SSF52954 | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |