About Gene List

PF3D7_0729400

Genome location: Pf3D7_07_v3:1,252,237..1,254,478(+)

Genome classification: Core

Function and Localization

Product Description: ribosome biogenesis protein BRX1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005730 nucleolus
Component GO:0005634 nucleus
Component GO:0030687 preribosome, large subunit precursor
Process GO:0000027 ribosomal large subunit assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.54 0.74
Trophozoite expressed 0.33 0.81
Schizont expressed 0.06 0.96
Gametocyte expressed 0.30 0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0729400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.865 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0213500)

  • Relative Growth Rate: 0.24 ± 0.29
  • Confidence: 3.83

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBG5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101913

Most Similar Human Ortholog: Q8TDN6

TM-align score: 0.62 | RMSD: 2.79

Seq Identity: 0.37 | Length: 241 / 416

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000113460 biogenesis of ribosomes BRX1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 22 12 21
disruptive 24 64 26 64
missense 9 46 14 45

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 42 15 14
disruptive 32 109 37 88
missense 14 73 27 58

PlasmoDB Total SNPs: 216

Non-coding: 74 | Synonymous: 30 | Nonsynonymous: 112 | Stop Codon: 0

Protein Information

Protein Length: 416 | Molecular Weight (kDa): 49.531

UniProt ID(s): Q8IBG5

PDB ID(s): None

Isoelectric Point: 4.08

Protein Domain Annotations:

Source Family ID Description
InterPro IPR007109 Brix domain
InterPro IPR026532 Ribosome biogenesis protein BRX1
PFam PF04427 Brix domain
Superfamily SSF52954 N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108