About Gene List

PF3D7_0729600 (CMC1)

Genome location: Pf3D7_07_v3:1,258,496..1,260,113(+)

Genome classification: Core

Function and Localization

Product Description: COX assembly mitochondrial protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed nd nd
Trophozoite not expressed nd nd
Schizont expressed nd nd
Gametocyte possibly expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0729600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.989 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZXB4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_133979

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 8 4 13
disruptive 0 14 5 13
missense 0 12 5 12

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 15 8 11
disruptive 3 26 8 35
missense 1 20 7 25

PlasmoDB Total SNPs: 76

Non-coding: 68 | Synonymous: 8 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 163 | Molecular Weight (kDa): 20.13

UniProt ID(s): A0A143ZXB4

PDB ID(s): None

Isoelectric Point: 9.81

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013892 Cytochrome c oxidase biogenesis protein Cmc1-like
PFam PF08583 Cytochrome c oxidase biogenesis protein Cmc1-like
Superfamily N/A N/A

Associated Publications

No associated publications