PF3D7_0729700

Genome location: Pf3D7_07_v3:1,259,830..1,262,801(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	not expressed	0.05	0.97
Schizont	expressed	0.69	0.66
Gametocyte	expressed	0.55	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0729700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.104 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBG3

"Best" AlphaFill ligand hit: MTA (5'-deoxy-5'-methylthioadenosine, Local RMSD=5.55) with 8CXS (Global RMSD=15.82)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156390

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	34	16	30
disruptive	19	86	42	105
missense	19	84	42	97

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	55	33	34
disruptive	30	189	78	170
missense	26	162	68	125

PlasmoDB Total SNPs: 153

Non-coding: 83 | Synonymous: 46 | Nonsynonymous: 23 | Stop Codon: 1

Protein Information

Protein Length: 802 | Molecular Weight (kDa): 96.829

UniProt ID(s): Q8IBG3

PDB ID(s): None

Isoelectric Point: 8.66

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF144232	N/A