PF3D7_0729800

Genome location: Pf3D7_07_v3:1,263,193..1,264,952(+)

Genome classification: Core

Function and Localization

Product Description: dynein light chain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030286	dynein complex
Component	GO:0005875	microtubule associated complex
Function	GO:0045505	dynein intermediate chain binding
Function	GO:0051959	dynein light intermediate chain binding
Function	GO:0003777	microtubule motor activity
Process	GO:0007018	microtubule-based movement
Process	GO:2000582	obsolete positive regulation of microtubule motor activity, plus-end-directed

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.00	1.00
Schizont	no data	0.05	0.97
Gametocyte	no data	0.13	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0729800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.186 | MFS: -3.884 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0213900)

Relative Growth Rate: 1.03 ± 0.13
Confidence: 5.40

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0213900)

Modification: Disrupted | RMgm-1731

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBG2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533534

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	4	1	4
disruptive	0	6	3	8
missense	0	5	3	8

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	7	3	2
disruptive	4	19	5	25
missense	1	16	5	13

PlasmoDB Total SNPs: 80

Non-coding: 71 | Synonymous: 9 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 97 | Molecular Weight (kDa): 11.676

UniProt ID(s): Q8IBG2

PDB ID(s): None

Isoelectric Point: 7.48

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001372	Dynein light chain, type 1/2
InterPro	IPR037177	Dynein light chain superfamily
PFam	PF01221	Dynein light chain, type 1/2
Superfamily	SSF54648	Dynein light chain superfamily