PF3D7_0730000

Genome location: Pf3D7_07_v3:1,280,794..1,282,452(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	possibly expressed	0.03	0.98
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.07	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0730000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.277 | MFS: -3.414 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBG0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160732

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	rare	doubleton	singleton
synonymous	9	2	3
disruptive	5	7	9
missense	5	7	7

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	8	5	4
disruptive	2	20	5	19
missense	2	17	3	13

PlasmoDB Total SNPs: 86

Non-coding: 81 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 1

Protein Information

Protein Length: 116 | Molecular Weight (kDa): 13.58

UniProt ID(s): Q8IBG0

PDB ID(s): None

Isoelectric Point: 10.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A