About Gene List

PF3D7_0730200

Genome location: Pf3D7_07_v3:1,286,026..1,290,117(-)

Genome classification: Core

Function and Localization

Product Description: AP-4 complex subunit beta, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0030130 clathrin coat of trans-Golgi network vesicle
Component GO:0005737 cytoplasm
Process GO:0016192 vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.15 0.92
Trophozoite not expressed 0.23 0.85
Schizont not expressed 0.09 0.94
Gametocyte not expressed 0.16 0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0730200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.134 | MFS: -3.071 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_0215700)

Modification: Tagged | RMgm-1513

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBF8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105105

Most Similar Human Ortholog: B1ALD2

TM-align score: 0.94 | RMSD: 1.63

Seq Identity: 0.39 | Length: 260 / 858

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000134262 adaptor related protein complex 4 subunit beta 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 33 29 59
disruptive 9 66 31 108
missense 9 62 29 91

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 80 34 42
disruptive 27 180 81 225
missense 20 136 67 132

PlasmoDB Total SNPs: 173

Non-coding: 138 | Synonymous: 24 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 858 | Molecular Weight (kDa): 100.381

UniProt ID(s): Q8IBF8

PDB ID(s): None

Isoelectric Point: 5.33

Protein Domain Annotations:

Source Family ID Description
InterPro IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
InterPro IPR015151 Beta-adaptin appendage, C-terminal subdomain
InterPro IPR016024 Armadillo-type fold
InterPro IPR016342 AP-1/2/4 complex subunit beta
InterPro IPR026739 AP complex subunit beta
PFam PF01602 Clathrin/coatomer adaptor, adaptin-like, N-terminal
PFam PF09066 Beta-adaptin appendage, C-terminal subdomain
Superfamily SSF48371 Armadillo-type fold

Associated Publications

PMID Title Authors DOI/Link
27434123 Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates forCombination Vaccines with Circumsporozoite Protein. Speake C, Pichugin A, ..., Duffy PE 10.1371/journal.pone.0159449