Product Description: AP-4 complex subunit beta, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0030130 | clathrin coat of trans-Golgi network vesicle |
Component | GO:0005737 | cytoplasm |
Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | not expressed | 0.15 | 0.92 |
Trophozoite | not expressed | 0.23 | 0.85 |
Schizont | not expressed | 0.09 | 0.94 |
Gametocyte | not expressed | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0730200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.134 | MFS: -3.071 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PY17X_0215700)
Modification: Tagged | RMgm-1513
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBF8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105105
Most Similar Human Ortholog: B1ALD2
TM-align score: 0.94 | RMSD: 1.63
Seq Identity: 0.39 | Length: 260 / 858
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000134262 | adaptor related protein complex 4 subunit beta 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 5 | 33 | 29 | 59 |
disruptive | 9 | 66 | 31 | 108 |
missense | 9 | 62 | 29 | 91 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 15 | 80 | 34 | 42 |
disruptive | 27 | 180 | 81 | 225 |
missense | 20 | 136 | 67 | 132 |
PlasmoDB Total SNPs: 173
Non-coding: 138 | Synonymous: 24 | Nonsynonymous: 11 | Stop Codon: 0
Protein Length: 858 | Molecular Weight (kDa): 100.381
UniProt ID(s): Q8IBF8
PDB ID(s): None
Isoelectric Point: 5.33
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR002553 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
InterPro | IPR015151 | Beta-adaptin appendage, C-terminal subdomain |
InterPro | IPR016024 | Armadillo-type fold |
InterPro | IPR016342 | AP-1/2/4 complex subunit beta |
InterPro | IPR026739 | AP complex subunit beta |
PFam | PF01602 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
PFam | PF09066 | Beta-adaptin appendage, C-terminal subdomain |
Superfamily | SSF48371 | Armadillo-type fold |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
27434123 | Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates forCombination Vaccines with Circumsporozoite Protein. | Speake C, Pichugin A, ..., Duffy PE | 10.1371/journal.pone.0159449 |