Genome location: Pf3D7_07_v3:1,304,347..1,305,096(+)
Genome classification: Core
Product Description: IMP1-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.17 | 0.92 |
| Trophozoite | not expressed | 0.03 | 0.98 |
| Schizont | not expressed | 0.61 | 0.74 |
| Gametocyte | not expressed | 0.10 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0730400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.465 | MFS: -1.239 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0214500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0214500)
Modification: Disrupted | RMgm-1734
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBF5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 8 | 3 | 11 |
| disruptive | 0 | 0 | 1 | 7 |
| missense | 0 | 0 | 1 | 6 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 16 | 4 | 8 |
| disruptive | 0 | 7 | 11 | 24 |
| missense | 0 | 4 | 6 | 19 |
PlasmoDB Total SNPs: 23
Non-coding: 19 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 158 | Molecular Weight (kDa): 17.801
UniProt ID(s): Q8IBF5
PDB ID(s): 5LG9
Isoelectric Point: 9.98
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR040785 | Immune Mapped Protein 2, C-terminal domain |
| InterPro | IPR040955 | Immune mapped protein 2, N-terminal |
| PFam | PF18590 | Immune mapped protein 2, N-terminal |
| PFam | PF18591 | Immune Mapped Protein 2, C-terminal domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 37158439 | The fission yeast cytokinetic ring component Fic1 promotes septum formation | Rossi AM, Bohnert KA, Gould KL | 10.1242/bio.059957 |
| 36993237 | The fission yeast cytokinetic ring component Fic1 promotes septum formation | Rossi AM, Bohnert KA, Gould KL | 10.1101/2023.03.13.532462 |