About Gene List

PF3D7_0730500

Genome location: Pf3D7_07_v3:1,305,154..1,315,639(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.25 0.88
Trophozoite possibly expressed 1.06 0.49
Schizont possibly expressed 1.72 0.26
Gametocyte not expressed 0.87 0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0730500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.707 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532675

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 21 133 43 124
disruptive 125 353 163 427
missense 79 302 131 348

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 57 194 74 183
disruptive 240 685 299 747
missense 149 522 232 481

PlasmoDB Total SNPs: 428

Non-coding: 144 | Synonymous: 163 | Nonsynonymous: 121 | Stop Codon: 0

Protein Information

Protein Length: 2773 | Molecular Weight (kDa): 329.466

UniProt ID(s): Q8IBF4

PDB ID(s): None

Isoelectric Point: 9.67

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108