PF3D7_0730800

Genome location: Pf3D7_07_v3:1,320,155..1,323,192(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043657	host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	possibly expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0730800.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.895 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBF3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532983

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	14	8	15
disruptive	34	58	18	58
missense	17	24	9	30

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	23	11	19
disruptive	52	97	38	89
missense	26	43	25	47

PlasmoDB Total SNPs: 116

Non-coding: 70 | Synonymous: 22 | Nonsynonymous: 24 | Stop Codon: 0

Protein Information

Protein Length: 293 | Molecular Weight (kDa): 32.098

UniProt ID(s): Q8IBF3, Q9NFG7, Q9NFG8

PDB ID(s): None

Isoelectric Point: 4.62

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR016024	Armadillo-type fold
PFam	N/A	N/A
Superfamily	SSF48371	Armadillo-type fold