About Gene List

PF3D7_0730900 (PTP4)

Genome location: Pf3D7_07_v3:1,324,452..1,333,940(+)

Genome classification: Core

Function and Localization

Product Description: EMP1-trafficking protein

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 1.51 0.44
Trophozoite expressed 0.73 0.70
Schizont expressed 0.33 0.83
Gametocyte not expressed 0.25 0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0730900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.024 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBF2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_120018

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 20 18 27
disruptive 21 51 35 103
missense 21 50 34 89

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 36 21 26
disruptive 35 126 79 143
missense 32 106 64 95

PlasmoDB Total SNPs: 495

Non-coding: 106 | Synonymous: 238 | Nonsynonymous: 150 | Stop Codon: 1

Protein Information

Protein Length: 2110 | Molecular Weight (kDa): 244.195

UniProt ID(s): Q8IBF2

PDB ID(s): None

Isoelectric Point: 6.94

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596
33774908 Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. Jonsdottir TK, Counihan NA, ..., Gilson PR 10.1111/cmi.13332
30036623 Chemical characterization and antioxidant activities of polysaccharides isolatedfrom the stems of Parthenocissus tricuspidata Liang X, Gao Y, ..., Zhang W 10.1016/j.ijbiomac.2018.07.131
11955632 A potential membrane protein involved in pre-tRNA splicing of Schizosaccharomycespombe Kim M, Hwang K, Lim CJ, Kim D 10.1016/s0167-4781(01)00353-0