About Gene List

PF3D7_0731100 (PTP2)

Genome location: Pf3D7_07_v3:1,336,751..1,342,768(+)

Genome classification: Core

Function and Localization

Product Description: EMP1-trafficking protein

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Process GO:0006900 vesicle budding from membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 2.05 0.25
Trophozoite expressed 0.49 0.74
Schizont expressed 0.57 0.67
Gametocyte possibly expressed 0.35 0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0731100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.299 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBF1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532695

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 23 12 29
disruptive 21 71 32 111
missense 21 70 30 97

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 42 24 36
disruptive 34 145 83 203
missense 30 128 71 154

PlasmoDB Total SNPs: 183

Non-coding: 144 | Synonymous: 21 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 890 | Molecular Weight (kDa): 103.069

UniProt ID(s): Q8IBF1

PDB ID(s): None

Isoelectric Point: 6.91

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006526 Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
18614010 Exported proteins required for virulence and rigidity of Plasmodiumfalciparum-infected human erythrocytes. Maier AG, Rug M, ..., Cowman AF 10.1016/j.cell.2008.04.051
23683579 Cell-cell communication between malaria-infected red blood cells via exosome-likevesicles. Regev-Rudzki N, Wilson DW, ..., Cowman AF 10.1016/j.cell.2013.04.029
36870684 Two activating phosphorylation sites of Pbs2 MAP2K in the yeast HOG pathway aredifferentially dephosphorylated by four PP2C phosphatases Ptc1-Ptc4 Tatebayashi K, Saito H 10.1016/j.jbc.2023.104569