About Gene List

PF3D7_0731200

Genome location: Pf3D7_07_v3:1,342,335..1,344,508(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.69 0.68
Trophozoite not expressed 0.15 0.91
Schizont not expressed 0.09 0.94
Gametocyte not expressed 0.04 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0731200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.993 | MFS: -1.571 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBF0

"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=9.70) with 1ONF (Global RMSD=12.58)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532561

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 6 4 17
disruptive 2 19 12 53
missense 2 18 11 48

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 12 10 21
disruptive 9 58 40 66
missense 7 47 38 60

PlasmoDB Total SNPs: 65

Non-coding: 42 | Synonymous: 17 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 309 | Molecular Weight (kDa): 37.026

UniProt ID(s): Q8IBF0

PDB ID(s): None

Isoelectric Point: 6.37

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g