PF3D7_0731700

Genome location: Pf3D7_07_v3:1,371,309..1,372,884(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp9), unknown function

SignalP Peptide: MFVLLYKIFLLSLFVINLIYV

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043657	host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	possibly expressed	0.08	0.94
Schizont	possibly expressed	0.02	0.98
Gametocyte	not expressed	0.01	1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0731700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.957 | MFS: -2.381 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBE7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_149546

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	3	1	7
disruptive	13	28	15	24
missense	11	25	13	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	11	2	8
disruptive	27	45	18	30
missense	21	39	13	13

PlasmoDB Total SNPs: 51

Non-coding: 37 | Synonymous: 7 | Nonsynonymous: 6 | Stop Codon: 1

Protein Information

Protein Length: 196 | Molecular Weight (kDa): 23.175

UniProt ID(s): Q8IBE7

PDB ID(s): None

Isoelectric Point: 9.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A