About Gene List

PF3D7_0731800 (GEXP08)

Genome location: Pf3D7_07_v3:1,376,748..1,380,999(+)

Genome classification: Core

Function and Localization

Product Description: alpha/beta hydrolase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: 3.1.1.5 (Lysophospholipase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane
Function GO:0016298 lipase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.43 0.79
Trophozoite not expressed 0.10 0.94
Schizont expressed 0.20 0.88
Gametocyte expressed 0.64 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0731800

Resistome Missense Mutations: A332T

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.781 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4Q4

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
3.1.1.5 lysophospholipase NEMSDSEDTAPCMBEGTAPMSFDMSOCaCl2FeCl3xyleneethanolsulfite...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_157547

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 10 8 17
disruptive 27 47 19 58
missense 23 39 16 41

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 21 15 15
disruptive 38 113 51 134
missense 28 80 39 79

PlasmoDB Total SNPs: 132

Non-coding: 79 | Synonymous: 26 | Nonsynonymous: 26 | Stop Codon: 1

Protein Information

Protein Length: 675 | Molecular Weight (kDa): 78.379

UniProt ID(s): C0H4Q4

PDB ID(s): None

Isoelectric Point: 7.79

Protein Domain Annotations:

Source Family ID Description
InterPro IPR022742 Serine aminopeptidase, S33
InterPro IPR029058 Alpha/Beta hydrolase fold
PFam PF12146 Serine aminopeptidase, S33
Superfamily SSF53474 Alpha/Beta hydrolase fold

Associated Publications

No associated publications