Genome location: Pf3D7_07_v3:1,376,748..1,380,999(+)
Genome classification: Core
Product Description: alpha/beta hydrolase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 3.1.1.5 (Lysophospholipase)
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0016020 | membrane |
Function | GO:0016298 | lipase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | expressed | 0.43 | 0.79 |
Trophozoite | not expressed | 0.10 | 0.94 |
Schizont | expressed | 0.20 | 0.88 |
Gametocyte | expressed | 0.64 | 0.66 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0731800
Resistome Missense Mutations: A332T
Resistome Compounds with Missense Mutations: BI-2536
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.781 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4Q4
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
EC # | Name | EC Inhibitors |
---|---|---|
3.1.1.5 | lysophospholipase | NEMSDSEDTAPCMBEGTAPMSFDMSOCaCl2FeCl3xyleneethanolsulfite... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 7 | 10 | 8 | 17 |
disruptive | 27 | 47 | 19 | 58 |
missense | 23 | 39 | 16 | 41 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 10 | 21 | 15 | 15 |
disruptive | 38 | 113 | 51 | 134 |
missense | 28 | 80 | 39 | 79 |
PlasmoDB Total SNPs: 132
Non-coding: 79 | Synonymous: 26 | Nonsynonymous: 26 | Stop Codon: 1
Protein Length: 675 | Molecular Weight (kDa): 78.379
UniProt ID(s): C0H4Q4
PDB ID(s): None
Isoelectric Point: 7.79
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR022742 | Serine aminopeptidase, S33 |
InterPro | IPR029058 | Alpha/Beta hydrolase fold |
PFam | PF12146 | Serine aminopeptidase, S33 |
Superfamily | SSF53474 | Alpha/Beta hydrolase fold |
No associated publications