About Gene List

PF3D7_0732700 (RIF)

Genome location: Pf3D7_07_v3:1,408,781..1,409,975(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: rifin

SignalP Peptide: MKLLYSNILLFALALNILLTSYYA

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020002 host cell plasma membrane
Process GO:0020033 antigenic variation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.00 1.00
Trophozoite no data 0.00 1.00
Schizont no data nd 1.00
Gametocyte no data nd 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0732700

Resistome Missense Mutations: L111V, P146H, A147S, A293V

Resistome Compounds with Missense Mutations: AN13956, MMV019066, MMV407834

Resistome # Samples with Disruptive Mutations: 12 (6 missense, 4 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.473 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4Q7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100719

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 490

Non-coding: 32 | Synonymous: 106 | Nonsynonymous: 349 | Stop Codon: 3

Protein Information

Protein Length: 359 | Molecular Weight (kDa): 40.173

UniProt ID(s): A0A4V1EKD1, A0A4V1EKD3, C0H4Q7, Q2XRB1

PDB ID(s): None

Isoelectric Point: 9.37

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006373 Variant surface antigen Rifin
PFam PF02009 Variant surface antigen Rifin
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10430943 Rifins: a second family of clonally variant proteins expressed on the surface ofred cells infected with Plasmodium falciparum. Kyes SA, Rowe JA, Kriek N, Newbold CI 10.1073/pnas.96.16.9333
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094