PF3D7_0732800

Genome location: Pf3D7_07_v3:1,410,435..1,412,231(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: erythrocyte membrane protein 1 (PfEMP1), exon 2

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0732800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.991 | MFS: -1.756 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZXL1

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 671

Non-coding: 158 | Synonymous: 263 | Nonsynonymous: 243 | Stop Codon: 7

Protein Information

Protein Length: 442 | Molecular Weight (kDa): 50.614

UniProt ID(s): A0A143ZXL1, A0A5P1A0G5, A0A5P1A0K9, A0A5P1A1E5, A0A5P1A1L7, Q6UDW6

PDB ID(s): None

Isoelectric Point: 4.42

Protein Domain Annotations: