PF3D7_0800700 (SURF8.3)

Genome location: Pf3D7_08_v3:65,153..74,000(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: surface-associated interspersed protein 8.3 (SURFIN 8.3)

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0009986	cell surface
Component	GO:0044228	host cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	possibly expressed	0.06	0.97
Schizont	not expressed	0.09	0.94
Gametocyte	possibly expressed	0.16	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0800700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 4 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.181 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZWG8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134606

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 742

Non-coding: 208 | Synonymous: 250 | Nonsynonymous: 281 | Stop Codon: 3

Protein Information

Protein Length: 1925 | Molecular Weight (kDa): 235.057

UniProt ID(s): A0A143ZWG8, A0A1Y1CDI6, A0A1Y1CE47, A0A1Y1CED9, A0A348FV61, A0A348FV76

PDB ID(s): None

Isoelectric Point: 5.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR024288	Schizont-infected cell agglutination, C-terminal domain
PFam	PF12879	Schizont-infected cell agglutination, C-terminal domain
Superfamily	N/A	N/A