PF3D7_0800800

Genome location: Pf3D7_08_v3:79,126..80,766(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp7), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043657	host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.03	0.98
Trophozoite	expressed	0.06	0.97
Schizont	expressed	0.07	0.96
Gametocyte	possibly expressed	0.00	1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0800800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -2.927 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAK7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215315

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	11	5	11
disruptive	16	26	16	31
missense	14	22	14	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	21	6	15
disruptive	25	63	26	51
missense	18	44	22	34

PlasmoDB Total SNPs: 151

Non-coding: 128 | Synonymous: 5 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 209 | Molecular Weight (kDa): 24.712

UniProt ID(s): Q8IAK7

PDB ID(s): None

Isoelectric Point: 9.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A