Product Description: Plasmodium exported protein (PHISTc)
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0005634 | nucleus |
| Component | GO:0032991 | protein-containing complex |
| Component | GO:0020008 | rhoptry |
| Function | GO:0005515 | protein binding |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.97 | 0.29 |
| Trophozoite | expressed | 0.95 | 0.54 |
| Schizont | expressed | 0.41 | 0.77 |
| Gametocyte | not expressed | 0.33 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0801000
Resistome Missense Mutations: P1063S
Resistome Compounds with Missense Mutations: MMV1454442
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.978 | MFS: -3.004 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1229000)
Modification: Tagged | RMgm-4424
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IAK9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 30 | 11 | 30 |
| disruptive | 46 | 90 | 51 | 105 |
| missense | 26 | 67 | 42 | 86 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 39 | 15 | 34 |
| disruptive | 73 | 161 | 55 | 137 |
| missense | 46 | 119 | 49 | 88 |
PlasmoDB Total SNPs: 542
Non-coding: 130 | Synonymous: 242 | Nonsynonymous: 170 | Stop Codon: 0
Protein Length: 1219 | Molecular Weight (kDa): 147.069
UniProt ID(s): Q8IAK9
PDB ID(s): None
Isoelectric Point: 5.86
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006526 | Exported protein, PHISTa/b/c, conserved domain, Plasmodium |
| InterPro | IPR019111 | Plasmodium RESA, N-terminal |
| PFam | PF09687 | Plasmodium RESA, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 29487358 | PV1, a novel Plasmodium falciparum merozoite dense granule protein, interactswith exported protein in infected erythrocytes. | Morita M, Nagaoka H, ..., Takashima E | 10.1038/s41598-018-22026-0 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 33147497 | Characterization of a Plasmodium falciparum PHISTc protein, PF3D7_0801000, inblood- stage malaria parasites. | Nagaoka H, Kanoi BN, ..., Takashima E | 10.1016/j.parint.2020.102240 |