PF3D7_0801300 (WARP)

Genome location: Pf3D7_08_v3:101,954..102,826(-)

Genome classification: Core

Function and Localization

Product Description: von Willebrand factor A domain-related protein

SignalP Peptide: MKSLKVVLCLGMISACMLVGTYG

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0034494	microneme lumen
Function	GO:0050693	LBD domain binding
Function	GO:0050839	cell adhesion molecule binding
Function	GO:0008201	heparin binding
Process	GO:0007155	cell adhesion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.02	0.99
Trophozoite	no data	0.01	0.99
Schizont	no data	0.01	0.99
Gametocyte	no data	0.09	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0801300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.324 | MFS: -2.353 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1116000)

Relative Growth Rate: 0.95 ± 0.20
Confidence: 4.65

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1228900)

Modification: Disrupted | RMgm-87

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAL0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_209138

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	6	7	15
disruptive	7	4	7	17
missense	7	4	7	16

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	20	5	19
disruptive	9	19	13	51
missense	9	13	12	38

PlasmoDB Total SNPs: 15

Non-coding: 0 | Synonymous: 6 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 290 | Molecular Weight (kDa): 31.959

UniProt ID(s): Q8IAL0

PDB ID(s): None

Isoelectric Point: 4.55

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002035	von Willebrand factor, type A
InterPro	IPR036465	von Willebrand factor A-like domain superfamily
PFam	PF00092	von Willebrand factor, type A
Superfamily	SSF53300	von Willebrand factor A-like domain superfamily