PF3D7_0801600

Genome location: Pf3D7_08_v3:108,965..109,811(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.04	0.97
Schizont	possibly expressed	0.02	0.99
Gametocyte	possibly expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0801600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.999 | MFS: -2.633 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAL4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156419

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	3	1	11
disruptive	2	5	1	12
missense	2	5	1	12

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	10	7	8
disruptive	4	18	8	23
missense	4	13	7	12

PlasmoDB Total SNPs: 40

Non-coding: 25 | Synonymous: 9 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 125 | Molecular Weight (kDa): 14.793

UniProt ID(s): Q8IAL4

PDB ID(s): None

Isoelectric Point: 9.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A