Product Description: sentrin-specific protease 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.4.22.68 (Ulp1 peptidase);5.3.1.8 (Mannose-6-phosphate isomerase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0008234 | cysteine-type peptidase activity |
| Process | GO:0006508 | proteolysis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.34 | 0.84 |
| Trophozoite | expressed | 1.23 | 0.41 |
| Schizont | expressed | 0.31 | 0.82 |
| Gametocyte | expressed | 0.94 | 0.53 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0801700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.524 | MFS: -2.502 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1228500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4Y4
"Best" AlphaFill ligand hit: AYE (allylamine, Local RMSD=0.40) with 7R2E (Global RMSD=4.94)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.22.68 | Ulp1 peptidase | Gu-HClVEA-260hSUMO-VSN-ethylmaleimideUbiquitin aldehyde3-[(4-[[2-[(2E)-4-[bis(naphthalen-1-ylmethyl)amino]-4-oxobut-2-enoyl]-2-(carboxymethyl)hydrazinyl]carbonyl]benzyl)carbamoyl]benzoic acid3-[(4-[[2-[4-[bis(naphthalen-1-ylmethyl)amino]-2,3-dichloro-4-oxobutanoyl]-2-(carboxymethyl)hydrazinyl]carbonyl]benzyl)carbamoyl]benzoic acid3-[(4-[[2-[4-[bis(naphthalen-1-ylmethyl)amino]-3-chloro-2-hydroxy-4-oxobutanoyl]-2-(carboxymethyl)hydrazinyl]carbonyl]benzyl)carbamoyl]benzoic acid3-[(4-[[2-([(2R,3R)-3-[benzyl(cyclohexa-1,3-dien-1-ylmethyl)carbamoyl]-3-chlorooxiran-2-yl]carbonyl)-2-(carboxymethyl)hydrazinyl]carbonyl]benzyl)carbamoyl]benzoic acid |
| 5.3.1.8 | mannose-6-phosphate isomerase | EDTAPCMBHgCl2cysteinephosphateGDP-mannoseADP-glucoseGDP-D-mannosedithiothreitol2,2'-dipyridylL-ascorbic acid2,3-Butanedione... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_113308
Most Similar Human Ortholog: D6RJH1
TM-align score: 0.45 | RMSD: 4.15
Seq Identity: 0.01 | Length: 66 / 1784
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000112701 | SUMO specific peptidase 6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 18 | 94 | 57 | 86 |
| disruptive | 116 | 325 | 137 | 282 |
| missense | 55 | 221 | 112 | 228 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 34 | 170 | 55 | 105 |
| disruptive | 214 | 538 | 208 | 405 |
| missense | 102 | 385 | 162 | 285 |
PlasmoDB Total SNPs: 458
Non-coding: 201 | Synonymous: 128 | Nonsynonymous: 129 | Stop Codon: 0
Protein Length: 1784 | Molecular Weight (kDa): 210.88
UniProt ID(s): C0H4Y4
PDB ID(s): None
Isoelectric Point: 6.58
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR038765 | Papain-like cysteine peptidase superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF54001 | Papain-like cysteine peptidase superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 36292935 | Discovery of a Dual SENP1 and SENP2 Inhibitor | Brand M, Bommeli EB, ..., Riedl R | 10.3390/ijms232012085 |