PF3D7_0801900 (LSD2)

Genome location: Pf3D7_08_v3:126,226..143,894(+)

Genome classification: Core

Function and Localization

Product Description: lysine-specific histone demethylase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 1.4.3.4 (Monoamine oxidase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0016491	oxidoreductase activity
Function	GO:0046592	polyamine oxidase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.87	0.65
Trophozoite	possibly expressed	0.64	0.70
Schizont	possibly expressed	0.34	0.83
Gametocyte	expressed	1.83	0.26

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0801900

Resistome Missense Mutations: N1397K, N1407K, N2490K, D3808Y

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.204 | #Insertions: 19

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
1.4.3.4	monoamine oxidase	BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156250

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	61	240	110	258
disruptive	345	870	386	879
missense	190	594	295	635

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	108	426	172	279
disruptive	636	1584	678	1307
missense	311	1109	475	759

PlasmoDB Total SNPs: 1229

Non-coding: 270 | Synonymous: 481 | Nonsynonymous: 474 | Stop Codon: 4

Protein Information

Protein Length: 4662 | Molecular Weight (kDa): 551.968

UniProt ID(s): C0H4R0

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002937	Amine oxidase
InterPro	IPR036188	FAD/NAD(P)-binding domain superfamily
PFam	PF01593	Amine oxidase
Superfamily	SSF51905	FAD/NAD(P)-binding domain superfamily

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
38181050	The Cross-Regulation Between Set1, Clr4, and Lsd1/2 in Schizosaccharomyces pombe	Liu H, Marayati BF, ..., Reid KZ	10.1371/journal.pgen.1011107