PF3D7_0802100 (AP2-LT)

Genome location: Pf3D7_08_v3:151,702..161,318(-)

Genome classification: Core

Function and Localization

Product Description: AP2 domain transcription factor AP2-LT

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0000123	histone acetyltransferase complex
Component	GO:0005634	nucleus
Function	GO:0043565	sequence-specific DNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.13	0.94
Trophozoite	possibly expressed	0.91	0.57
Schizont	expressed	2.14	0.21
Gametocyte	expressed	1.12	0.46

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0802100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.304 | MFS: -2.584 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAM1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533630

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	44	144	87	175
disruptive	162	460	231	564
missense	84	342	195	466

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	86	263	123	186
disruptive	285	928	416	795
missense	149	722	338	526

PlasmoDB Total SNPs: 503

Non-coding: 157 | Synonymous: 195 | Nonsynonymous: 151 | Stop Codon: 0

Protein Information

Protein Length: 2577 | Molecular Weight (kDa): 299.293

UniProt ID(s): Q8IAM1

PDB ID(s): None

Isoelectric Point: 8.49

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001471	AP2/ERF domain
PFam	PF00847	AP2/ERF domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
21060817	Identification and genome-wide prediction of DNA binding specificities for theApiAP2 family of regulators from the malaria parasite.	Campbell TL, De Silva EK, ..., Llinas M	10.1371/journal.ppat.1001165
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
34403450	A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion andvirulence in the malaria parasite Plasmodium falciparum.	Miao J, Wang C, ..., Cui L	10.1371/journal.ppat.1009351