Genome location: Pf3D7_08_v3:164,729..166,701(+)
Genome classification: Core
Product Description: 1-cys peroxiredoxin
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.11.1.15 (Transferred entry: 1.11.1.24)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0016209 | antioxidant activity |
| Function | GO:0004601 | peroxidase activity |
| Process | GO:0045454 | cell redox homeostasis |
| Process | GO:0006979 | response to oxidative stress |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.22 | 0.90 |
| Trophozoite | expressed | 1.40 | 0.40 |
| Schizont | expressed | 0.21 | 0.87 |
| Gametocyte | expressed | 0.38 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0802200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.956 | MFS: -2.441 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1430800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IAM2
"Best" AlphaFill ligand hit: FL0 (2-bromanyl-1-phenyl-ethanone, Local RMSD=0.09) with 7C89 (Global RMSD=3.04)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.11.1.15 | peroxiredoxin | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100111
Most Similar Human Ortholog: P30041
TM-align score: 0.96 | RMSD: 1.01
Seq Identity: 0.49 | Length: 218 / 220
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000117450 | peroxiredoxin 1 |
| ENSG00000117592 | peroxiredoxin 6 |
| ENSG00000123131 | peroxiredoxin 4 |
| ENSG00000165672 | peroxiredoxin 3 |
| ENSG00000167815 | peroxiredoxin 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 10 | 8 | 11 |
| disruptive | 4 | 14 | 8 | 25 |
| missense | 4 | 14 | 8 | 23 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 25 | 3 | 17 |
| disruptive | 5 | 40 | 26 | 48 |
| missense | 5 | 31 | 21 | 39 |
PlasmoDB Total SNPs: 106
Non-coding: 91 | Synonymous: 10 | Nonsynonymous: 4 | Stop Codon: 1
Protein Length: 220 | Molecular Weight (kDa): 25.164
UniProt ID(s): Q8IAM2, Q9GSV3, Q9XXW9
PDB ID(s): None
Isoelectric Point: 6.73
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000866 | Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant |
| InterPro | IPR019479 | Peroxiredoxin, C-terminal |
| InterPro | IPR024706 | Peroxiredoxin, AhpC-type |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| PFam | PF00578 | Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant |
| PFam | PF10417 | Peroxiredoxin, C-terminal |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 18692528 | 5' sequence- and chromatin modification-dependent gene expression in Plasmodiumfalciparum erythrocytic stage. | Komaki-Yasuda K, Okuwaki M, ..., Kawazu S | https://pubmed.ncbi.nlm.nih.gov/18692528/ |
| 21203490 | Compartmentation of redox metabolism in malaria parasites. | Kehr S, Sturm N, ..., Becker K | 10.1371/journal.ppat.1001242 |
| 30056630 | Tyrosine substitution of a conserved active-site histidine residue activatesPlasmodium falciparum peroxiredoxin 6. | Feld K, Geissel F, ..., Deponte M | 10.1002/pro.3490 |