PF3D7_0802400

Genome location: Pf3D7_08_v3:171,844..174,406(+)

Genome classification: Core

Function and Localization

Product Description: cyclin-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.71	0.67
Trophozoite	expressed	0.72	0.61
Schizont	expressed	0.21	0.87
Gametocyte	expressed	0.63	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0802400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.16 | MFS: -2.733 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1227800)

Relative Growth Rate: 0.05 ± 0.07
Confidence: 6.77

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAM4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_137940

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	27	15	39
disruptive	37	123	53	142
missense	14	85	46	107

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	57	28	45
disruptive	72	217	82	191
missense	31	155	62	119

PlasmoDB Total SNPs: 177

Non-coding: 78 | Synonymous: 57 | Nonsynonymous: 42 | Stop Codon: 0

Protein Information

Protein Length: 714 | Molecular Weight (kDa): 84.335

UniProt ID(s): Q8IAM4

PDB ID(s): None

Isoelectric Point: 8.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006671	Cyclin, N-terminal
InterPro	IPR013763	Cyclin-like
InterPro	IPR036915	Cyclin-like superfamily
PFam	PF00134	Cyclin, N-terminal
Superfamily	SSF47954	Cyclin-like superfamily