PF3D7_0802500

Genome location: Pf3D7_08_v3:174,618..180,248(-)

Genome classification: Core

Function and Localization

Product Description: inositol 5-phosphatase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: 3.1.3.36 (Phosphoinositide 5-phosphatase)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.17	0.91
Trophozoite	expressed	0.38	0.77
Schizont	expressed	0.89	0.51
Gametocyte	expressed	0.30	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0802500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.945 | MFS: -2.859 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1227700)

Relative Growth Rate: 0.36 ± 0.18
Confidence: 4.86

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1227700)

Modification: Disrupted | RMgm-3310

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4Q9

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.1.3.36	phosphoinositide 5-phosphatase	EDTAPCMBGSSGCutsumneomycinammonyx LOhemoglobinTriton X-100o-Iodosobenzoatesodium deoxycholatePhenylmercury acetate2,3-diphosphoglycerate...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101803

Most Similar Human Ortholog: A0A6Q8PGY4

TM-align score: 0.83 | RMSD: 2.99

Seq Identity: 0.29 | Length: 506 / 1419

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000112367	FIG4 phosphoinositide 5-phosphatase

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	64	32	68
disruptive	34	140	84	201
missense	25	127	71	159

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	110	54	80
disruptive	72	317	147	300
missense	47	232	115	223

PlasmoDB Total SNPs: 247

Non-coding: 111 | Synonymous: 83 | Nonsynonymous: 53 | Stop Codon: 0

Protein Information

Protein Length: 1419 | Molecular Weight (kDa): 173.061

UniProt ID(s): C0H4Q9

PDB ID(s): None

Isoelectric Point: 10.12

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002013	SAC domain
InterPro	IPR043573	Polyphosphoinositide phosphatase Fig4-like
PFam	PF02383	SAC domain
Superfamily	N/A	N/A