Product Description: adenylyl cyclase beta
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 4.6.1.1 (Adenylate cyclase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0020008 | rhoptry |
| Function | GO:0004016 | adenylate cyclase activity |
| Process | GO:0009268 | response to pH |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.14 | 0.93 |
| Trophozoite | expressed | 0.30 | 0.84 |
| Schizont | expressed | 2.64 | 0.11 |
| Gametocyte | expressed | 0.54 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0802600
Resistome Missense Mutations: N182K
Resistome Compounds with Missense Mutations: AN13762, AN13956
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.254 | MFS: -2.681 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1227600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4R1
"Best" AlphaFill ligand hit: APC (alpha,beta-methyleneadenosine-5'-triphosphate, Local RMSD=0.20) with 4CLK (Global RMSD=2.42)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 4.6.1.1 | adenylate cyclase | BRENDA SOAP query unsuccessful |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q96PN6 | Adenylate cyclase type 10 | Homo sapiens | OrthoDB, OrthoMCL BLAST | US10981899, Example RU-0204277-LRE1US10981899, Example RU-0204277-LRE1US10981899, Example RU-0207148US10981899, Example RU-0207148... |
| Q9Z286 | Adenylate cyclase type 10 | OrthoDB, OrthoMCL BLAST | CHEMBL5218698CHEMBL5220632CHEMBL5218878CHEMBL5218615... |
Protein Length: 2279 | Molecular Weight (kDa): 269.541
UniProt ID(s): C0H4R1
PDB ID(s): None
Isoelectric Point: 7.57
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001054 | Adenylyl cyclase class-3/4/guanylyl cyclase |
| InterPro | IPR029787 | Nucleotide cyclase |
| PFam | PF00211 | Adenylyl cyclase class-3/4/guanylyl cyclase |
| Superfamily | SSF55073 | Nucleotide cyclase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 25 | 86 | 36 | 109 |
| disruptive | 117 | 230 | 98 | 247 |
| missense | 60 | 147 | 71 | 184 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 37 | 139 | 71 | 129 |
| disruptive | 191 | 374 | 146 | 374 |
| missense | 76 | 270 | 104 | 267 |
PlasmoDB Total SNPs: 466
Non-coding: 138 | Synonymous: 161 | Nonsynonymous: 165 | Stop Codon: 2
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 22761895 | Characterization of Plasmodium falciparum adenylyl cyclase-beta and its role inerythrocytic stage parasites. | Salazar E, Bank EM, ..., Buck J | 10.1371/journal.pone.0039769 |
| 25522250 | The central role of cAMP in regulating Plasmodium falciparum merozoite invasionof human erythrocytes. | Dawn A, Singh S, ..., Chitnis CE | 10.1371/journal.ppat.1004520 |
| 31075098 | Cyclic AMP signalling controls key components of malaria parasite host cellinvasion machinery. | Patel A, Perrin AJ, ..., Baker DA | 10.1371/journal.pbio.3000264 |
| 26769898 | Structural and functional dissection of Toxoplasma gondii armadillo repeats onlyprotein | Mueller C, Samoo A, ..., Soldati-Favre D | 10.1242/jcs.177386 |