PF3D7_0802700

Genome location: Pf3D7_08_v3:188,566..190,316(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.07	0.96
Schizont	not expressed	0.09	0.94
Gametocyte	expressed	0.28	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0802700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.922 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1227500)

Relative Growth Rate: 1.03 ± 0.14
Confidence: 5.30

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1227500)

Modification: Disrupted | RMgm-3308

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAM7

"Best" AlphaFill ligand hit: NXL (nxl104, bound form, Local RMSD=0.19) with 7KEP (Global RMSD=13.07)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533499

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	14	9	22
disruptive	4	37	25	61
missense	4	37	25	60

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	29	16	25
disruptive	13	89	46	112
missense	9	76	41	86

PlasmoDB Total SNPs: 81

Non-coding: 54 | Synonymous: 17 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 410 | Molecular Weight (kDa): 49.246

UniProt ID(s): Q8IAM7

PDB ID(s): None

Isoelectric Point: 6.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A