About Gene List

PF3D7_0803100 (UTP14)

Genome location: Pf3D7_08_v3:198,725..203,315(-)

Genome classification: Core

Function and Localization

Product Description: U3 small nucleolar RNA-associated protein 14, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005730 nucleolus
Component GO:0032040 small-subunit processome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 1.29 0.46
Trophozoite expressed 1.11 0.45
Schizont expressed 0.54 0.68
Gametocyte expressed 0.78 0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0803100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.17 | MFS: -2.771 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAN1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532910

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 17 44 27 54
disruptive 89 175 94 212
missense 45 123 77 166

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 78 41 70
disruptive 145 376 136 285
missense 74 267 108 208

PlasmoDB Total SNPs: 371

Non-coding: 97 | Synonymous: 121 | Nonsynonymous: 153 | Stop Codon: 0

Protein Information

Protein Length: 1245 | Molecular Weight (kDa): 147.912

UniProt ID(s): Q8IAN1

PDB ID(s): None

Isoelectric Point: 5.01

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006709 Small-subunit processome, Utp14
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
32524281 Anti-infective nitazoxanide disrupts transcription of ribosome biogenesis-relatedgenes in yeast Xu S, Yamamoto N 10.1007/s13258-020-00958-0