About Gene List

PF3D7_0803200

Genome location: Pf3D7_08_v3:203,741..207,068(-)

Genome classification: Core

Function and Localization

Product Description: filament assembling protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.05 0.98
Trophozoite possibly expressed 0.32 0.81
Schizont expressed 1.54 0.36
Gametocyte expressed 0.64 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0803200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.827 | MFS: -2.363 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAN2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_111978

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 30 16 37
disruptive 34 88 54 91
missense 14 58 36 66

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 71 17 48
disruptive 60 196 78 189
missense 26 124 57 110

PlasmoDB Total SNPs: 237

Non-coding: 155 | Synonymous: 51 | Nonsynonymous: 31 | Stop Codon: 0

Protein Information

Protein Length: 728 | Molecular Weight (kDa): 86.743

UniProt ID(s): Q8IAN2

PDB ID(s): None

Isoelectric Point: 7.51

Protein Domain Annotations:

Source Family ID Description
InterPro IPR008374 SF-assemblin/beta-giardin
PFam PF06705 SF-assemblin/beta-giardin
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108