PF3D7_0803300 (MORG1)

Genome location: Pf3D7_08_v3:208,184..210,463(+)

Genome classification: Core

Function and Localization

Product Description: mitogen-activated protein kinase organizer 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005681	spliceosomal complex
Process	GO:0000398	mRNA splicing, via spliceosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	possibly expressed	0.12	0.92
Schizont	expressed	0.27	0.82
Gametocyte	expressed	0.13	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0803300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.98 | MFS: -2.486 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAN3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103232

Most Similar Human Ortholog: Q9BRX9

TM-align score: 0.89 | RMSD: 1.94

Seq Identity: 0.26 | Length: 296 / 365

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000123154	WD repeat domain 83

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	31	7	24
disruptive	2	28	13	45
missense	2	27	13	45

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	53	8	34
disruptive	9	72	24	88
missense	5	58	23	62

PlasmoDB Total SNPs: 138

Non-coding: 127 | Synonymous: 8 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 365 | Molecular Weight (kDa): 42.979

UniProt ID(s): Q8IAN3

PDB ID(s): None

Isoelectric Point: 8.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR019775	WD40 repeat, conserved site
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	PF00400	WD40 repeat
Superfamily	SSF50978	WD40-repeat-containing domain superfamily