PF3D7_0804300

Genome location: Pf3D7_08_v3:241,609..244,804(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Component	GO:0070761	pre-snoRNP complex
Process	GO:0000492	box C/D snoRNP assembly
Process	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Process	GO:0048254	snoRNA localization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.99	0.56
Trophozoite	possibly expressed	0.42	0.76
Schizont	not expressed	0.18	0.89
Gametocyte	expressed	0.64	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0804300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 5 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.146 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAN9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102819

Most Similar Human Ortholog: Q9NWK9

TM-align score: 0.39 | RMSD: 5.88

Seq Identity: 0.14 | Length: 246 / 890

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000117174	zinc finger HIT-type containing 6

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	39	19	42
disruptive	92	163	71	166
missense	50	106	50	120

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	61	24	46
disruptive	127	279	114	232
missense	67	188	85	140

PlasmoDB Total SNPs: 220

Non-coding: 18 | Synonymous: 98 | Nonsynonymous: 104 | Stop Codon: 0

Protein Information

Protein Length: 890 | Molecular Weight (kDa): 105.823

UniProt ID(s): Q8IAN9

PDB ID(s): None

Isoelectric Point: 4.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF144232	N/A