PF3D7_0804500

Genome location: Pf3D7_08_v3:248,516..268,538(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043291	RAVE complex
Component	GO:0016020	membrane
Process	GO:0007035	vacuolar acidification

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.72	0.69
Trophozoite	expressed	2.18	0.18
Schizont	expressed	1.92	0.31
Gametocyte	expressed	2.40	0.15

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0804500

Resistome Missense Mutations: I2842F

Resistome Compounds with Missense Mutations: Suloctidil

Resistome # Samples with Disruptive Mutations: 8 (2 missense, 2 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.177 | MFS: -2.745 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_114263

Most Similar Human Ortholog: Not available

TM-align score: 0.00 | RMSD: 0.00

Seq Identity: 0.00 | Length: / 6034

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000196156	keratin associated protein 4-3

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	69	260	128	312
disruptive	367	766	393	964
missense	181	549	323	753

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	117	490	237	328
disruptive	626	1587	686	1372
missense	291	1136	539	867

PlasmoDB Total SNPs: 944

Non-coding: 146 | Synonymous: 459 | Nonsynonymous: 339 | Stop Codon: 0

Protein Information

Protein Length: 6034 | Molecular Weight (kDa): 720.963

UniProt ID(s): A0A143ZZV5

PDB ID(s): None

Isoelectric Point: 8.95

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104