Product Description: tRNA pseudouridine synthase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 5.4.99.12 (tRNA pseudouridine(38-40) synthase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0009982 | pseudouridine synthase activity |
| Process | GO:1990481 | mRNA pseudouridine synthesis |
| Process | GO:0031119 | tRNA pseudouridine synthesis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.23 | 0.88 |
| Trophozoite | expressed | 0.26 | 0.83 |
| Schizont | possibly expressed | 0.08 | 0.95 |
| Gametocyte | not expressed | 0.17 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0804600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.915 | #Insertions: 10
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4R3
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.4.99.12 | tRNA pseudouridine38-40 synthase | tRNApoly(rA)npoly(rC)npoly(rG)npoly(rI)npoly(rU)niodoacetateCalf thymus DNADithionitrobenzoate5-fluorouracil tRNAPhep-chloromercuribenzoatefluorouracil-substituted tRNA |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101974
Most Similar Human Ortholog: F5H1S9
TM-align score: 0.77 | RMSD: 3.15
Seq Identity: 0.23 | Length: 321 / 556
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000177192 | pseudouridine synthase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 24 | 9 | 30 |
| disruptive | 13 | 42 | 28 | 65 |
| missense | 11 | 37 | 25 | 60 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 44 | 21 | 31 |
| disruptive | 24 | 113 | 68 | 128 |
| missense | 15 | 85 | 51 | 88 |
PlasmoDB Total SNPs: 194
Non-coding: 136 | Synonymous: 37 | Nonsynonymous: 20 | Stop Codon: 1
Protein Length: 556 | Molecular Weight (kDa): 66.597
UniProt ID(s): C0H4R3
PDB ID(s): None
Isoelectric Point: 8.26
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001406 | Pseudouridine synthase I, TruA |
| InterPro | IPR020097 | Pseudouridine synthase I, TruA, alpha/beta domain |
| InterPro | IPR020103 | Pseudouridine synthase, catalytic domain superfamily |
| InterPro | IPR041708 | Pseudouridine synthase PUS1/ PUS2-like |
| PFam | PF01416 | Pseudouridine synthase I, TruA, alpha/beta domain |
| Superfamily | SSF55120 | Pseudouridine synthase, catalytic domain superfamily |
No associated publications