PF3D7_0804700

Genome location: Pf3D7_08_v3:271,417..277,413(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.35	0.84
Trophozoite	not expressed	0.25	0.86
Schizont	possibly expressed	0.13	0.93
Gametocyte	expressed	2.17	0.28

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0804700

Resistome Missense Mutations: N1034K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.188 | #Insertions: 12

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZXC4

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.38) with 2HEK (Global RMSD=20.07)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532681

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	65	37	71
disruptive	93	233	146	381
missense	61	183	109	284

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	24	133	55	90
disruptive	196	557	250	525
missense	103	367	194	336

PlasmoDB Total SNPs: 283

Non-coding: 0 | Synonymous: 158 | Nonsynonymous: 124 | Stop Codon: 1

Protein Information

Protein Length: 1998 | Molecular Weight (kDa): 241.672

UniProt ID(s): A0A143ZXC4

PDB ID(s): None

Isoelectric Point: 10.37

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A