PF3D7_0805000

Genome location: Pf3D7_08_v3:282,505..285,200(-)

Genome classification: Core

Function and Localization

Product Description: alpha/beta hydrolase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	possibly expressed	0.04	0.97
Schizont	expressed	0.03	0.98
Gametocyte	not expressed	0.04	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0805000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.754 | MFS: -3.002 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1225600)

Relative Growth Rate: 1.03 ± 0.08
Confidence: 6.45

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1225600)

Modification: Disrupted | RMgm-3300

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4R4

"Best" AlphaFill ligand hit: OXE (ortho-xylene, Local RMSD=0.42) with 3E0X (Global RMSD=3.27)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100915

Most Similar Human Ortholog: Q96GS6

TM-align score: 0.94 | RMSD: 1.76

Seq Identity: 0.31 | Length: 243 / 245

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000107362	abhydrolase domain containing 17B, depalmitoylase
ENSG00000129968	abhydrolase domain containing 17A, depalmitoylase
ENSG00000136379	abhydrolase domain containing 17C, depalmitoylase

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	8	8	17
disruptive	1	8	5	22
missense	1	8	5	21

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	22	9	16
disruptive	4	20	13	64
missense	4	17	11	44

PlasmoDB Total SNPs: 127

Non-coding: 122 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 245 | Molecular Weight (kDa): 28.467

UniProt ID(s): C0H4R4

PDB ID(s): None

Isoelectric Point: 6.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022742	Serine aminopeptidase, S33
InterPro	IPR029058	Alpha/Beta hydrolase fold
PFam	PF12146	Serine aminopeptidase, S33
Superfamily	SSF53474	Alpha/Beta hydrolase fold