PF3D7_0805100

Genome location: Pf3D7_08_v3:286,432..289,198(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.27	0.84
Gametocyte	expressed	0.57	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0805100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.702 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1225500)

Relative Growth Rate: 0.98 ± 0.12
Confidence: 5.64

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1225500)

Modification: Disrupted | RMgm-3299

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAP6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533481

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	13	10	34
disruptive	9	25	17	65
missense	8	25	16	60

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	35	18	30
disruptive	14	77	45	91
missense	10	65	42	66

PlasmoDB Total SNPs: 55

Non-coding: 37 | Synonymous: 10 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 553 | Molecular Weight (kDa): 64.482

UniProt ID(s): Q8IAP6

PDB ID(s): None

Isoelectric Point: 9.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A