PF3D7_0805200 (GAMER)

Genome location: Pf3D7_08_v3:290,626..291,907(+)

Genome classification: Core

Function and Localization

Product Description: gamete release protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0805200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.929 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1225400)

• Relative Growth Rate: 0.99 ± 0.12
• Confidence: 5.60

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1225400)

Modification: Disrupted | RMgm-3298

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAP7

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533551

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 47

Non-coding: 46 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 1

Protein Information

Protein Length: 93 | Molecular Weight (kDa): 10.286

UniProt ID(s): Q8IAP7

PDB ID(s): None

Isoelectric Point: 4.28

Protein Domain Annotations: