PF3D7_0805300

Genome location: Pf3D7_08_v3:293,097..297,324(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.37	0.89
Trophozoite	not expressed	0.10	0.94
Schizont	possibly expressed	0.40	0.86
Gametocyte	expressed	0.97	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0805300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.399 | #Insertions: 8

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1225300)

Modification: Other | RMgm-444

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IAP8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532459

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	47	38	50
disruptive	20	140	88	204
missense	19	136	85	179

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	88	33	73
disruptive	48	327	125	286
missense	33	280	100	214

PlasmoDB Total SNPs: 103

Non-coding: 17 | Synonymous: 59 | Nonsynonymous: 27 | Stop Codon: 0

Protein Information

Protein Length: 1252 | Molecular Weight (kDa): 149.164

UniProt ID(s): Q8IAP8

PDB ID(s): None

Isoelectric Point: 8.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A