PF3D7_0805500

Genome location: Pf3D7_08_v3:304,814..310,547(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.65	0.70
Trophozoite	no data	0.34	0.79
Schizont	no data	0.36	0.77
Gametocyte	no data	0.40	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0805500

Resistome Missense Mutations: K50Q

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.173 | #Insertions: 9

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1225100)

Relative Growth Rate: 0.90 ± 0.22
Confidence: 4.45

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1225100)

Modification: Disrupted | RMgm-3296

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4R6

"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=1.62) with 1ONF (Global RMSD=17.01)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533754

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	45	18	58
disruptive	25	103	60	130
missense	17	80	50	96

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	83	41	69
disruptive	73	235	100	256
missense	41	164	76	155

PlasmoDB Total SNPs: 203

Non-coding: 122 | Synonymous: 39 | Nonsynonymous: 42 | Stop Codon: 0

Protein Information

Protein Length: 1084 | Molecular Weight (kDa): 128.693

UniProt ID(s): C0H4R6

PDB ID(s): None

Isoelectric Point: 8.96

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF101898	N/A