PF3D7_0805600 (PAP2)

Genome location: Pf3D7_08_v3:310,797..313,261(+)

Genome classification: Core

Function and Localization

Product Description: phosphatidic acid phosphatase 2

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: 3.1.3.4 (Phosphatidate phosphatase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane
Component	GO:0005886	plasma membrane
Function	GO:0042577	lipid phosphatase activity
Function	GO:0008195	phosphatidate phosphatase activity
Function	GO:0042392	sphingosine-1-phosphate phosphatase activity
Process	GO:0035891	exit from host cell
Process	GO:0006654	phosphatidic acid biosynthetic process
Process	GO:0046839	phospholipid dephosphorylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.85	0.62
Trophozoite	no data	0.53	0.69
Schizont	no data	0.47	0.70
Gametocyte	no data	0.19	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0805600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -3.088 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZY93

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.1.3.4	phosphatidate phosphatase	ATPGTPCTPNEMSDSNaFEDTAPCMBDMSOHgCl2CuSO4ZnCl2...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103418

Most Similar Human Ortholog: Q86YN1

TM-align score: 0.65 | RMSD: 3.02

Seq Identity: 0.17 | Length: 178 / 308

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000167130	dolichyldiphosphatase 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	15	7	15
disruptive	4	20	8	20
missense	4	20	8	16

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	22	8	15
disruptive	11	34	25	54
missense	10	26	20	27

PlasmoDB Total SNPs: 75

Non-coding: 54 | Synonymous: 15 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 308 | Molecular Weight (kDa): 35.85

UniProt ID(s): A0A143ZY93

PDB ID(s): None

Isoelectric Point: 10.01

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000326	Phosphatidic acid phosphatase type 2/haloperoxidase
InterPro	IPR036938	Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
PFam	PF01569	Phosphatidic acid phosphatase type 2/haloperoxidase
Superfamily	SSF48317	Phosphatidic acid phosphatase type 2/haloperoxidase superfamily