PF3D7_0805800

Genome location: Pf3D7_08_v3:322,367..323,677(-)

Genome classification: Core

Function and Localization

Product Description: CH domain-containing protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.01	0.99
Gametocyte	expressed	0.25	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0805800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.661 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZVZ5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533617

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	14	14	18
disruptive	18	32	22	47
missense	16	29	17	42

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	38	13	17
disruptive	26	87	42	107
missense	21	72	28	67

PlasmoDB Total SNPs: 25

Non-coding: 0 | Synonymous: 9 | Nonsynonymous: 15 | Stop Codon: 1

Protein Information

Protein Length: 436 | Molecular Weight (kDa): 53.172

UniProt ID(s): A0A143ZVZ5

PDB ID(s): None

Isoelectric Point: 9.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001715	Calponin homology domain
InterPro	IPR036872	CH domain superfamily
PFam	PF00307	Calponin homology domain
Superfamily	SSF47576	CH domain superfamily