PF3D7_0805900

Genome location: Pf3D7_08_v3:324,279..325,655(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0016791	phosphatase activity
Process	GO:0016311	dephosphorylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.07	0.96
Schizont	not expressed	0.01	0.99
Gametocyte	expressed	0.27	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0805900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.486 | MFS: -2.194 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1224800)

Relative Growth Rate: 0.35 ± 0.40
Confidence: 3.20

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZVL3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104275

Most Similar Human Ortholog: Q70Z53

TM-align score: 0.45 | RMSD: 3.93

Seq Identity: 0.34 | Length: 149 / 249

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000148690	FRA10A associated CGG repeat 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	20	9	15
disruptive	1	20	15	30
missense	1	18	13	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	30	11	25
disruptive	7	56	39	63
missense	4	39	31	42

PlasmoDB Total SNPs: 124

Non-coding: 106 | Synonymous: 16 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 249 | Molecular Weight (kDa): 30.2

UniProt ID(s): A0A143ZVL3

PDB ID(s): None

Isoelectric Point: 10.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019129	Folate-sensitive fragile site protein Fra10Ac1
PFam	PF09725	Folate-sensitive fragile site protein Fra10Ac1
Superfamily	N/A	N/A