PF3D7_0806000

Genome location: Pf3D7_08_v3:325,872..330,187(-)

Genome classification: Core

Function and Localization

Product Description: AAA family ATPase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0016887	ATP hydrolysis activity
Function	GO:1990275	preribosome binding
Process	GO:0051973	positive regulation of telomerase activity
Process	GO:0042254	ribosome biogenesis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.34	0.84
Trophozoite	expressed	0.71	0.62
Schizont	possibly expressed	0.13	0.92
Gametocyte	possibly expressed	0.59	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0806000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 6 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.143 | MFS: -2.854 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1224700)

Relative Growth Rate: 0.19 ± 0.22
Confidence: 4.45

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4S0

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.59) with 5Z6R (Global RMSD=1.82)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532300

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	42	30	52
disruptive	49	142	90	206
missense	25	116	74	183

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	82	36	69
disruptive	88	316	149	316
missense	48	234	122	236

PlasmoDB Total SNPs: 192

Non-coding: 78 | Synonymous: 77 | Nonsynonymous: 37 | Stop Codon: 0

Protein Information

Protein Length: 1212 | Molecular Weight (kDa): 145.702

UniProt ID(s): C0H4S0

PDB ID(s): None

Isoelectric Point: 9.66

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR003959	ATPase, AAA-type, core
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF00004	ATPase, AAA-type, core
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase