Product Description: Dpy-19-like C-mannosyltransferase
SignalP Peptide: N/A
# Transmembrane Domains: 9
EC Numbers: 2.4.1.- (Hexosyltransferases.)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005637 | nuclear inner membrane |
| Function | GO:0000030 | mannosyltransferase activity |
| Process | GO:0035891 | exit from host cell |
| Process | GO:0097502 | mannosylation |
| Process | GO:0018103 | protein C-linked glycosylation |
| Process | GO:0018406 | protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | not expressed | 0.12 | 0.92 |
| Schizont | expressed | 0.79 | 0.55 |
| Gametocyte | not expressed | 0.43 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0806200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.623 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1224500)
Modification: Disrupted | RMgm-5209
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4S1
"Best" AlphaFill ligand hit: CP6 (pyrimethamine, Local RMSD=8.43) with 3QGT (Global RMSD=16.95)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.4.1.- | Ex: levansucrase | KIATPADPUDPAMPGTPGDPCTPUTPKClNEMIMP... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_107418
Most Similar Human Ortholog: Q2PZI1
TM-align score: 0.87 | RMSD: 2.64
Seq Identity: 0.23 | Length: 625 / 1018
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000173852 | dpy-19 like C-mannosyltransferase 1 |
| ENSG00000177990 | dpy-19 like 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 30 | 33 | 46 |
| disruptive | 12 | 45 | 49 | 97 |
| missense | 8 | 43 | 42 | 80 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 88 | 40 | 55 |
| disruptive | 24 | 169 | 101 | 247 |
| missense | 14 | 122 | 78 | 129 |
PlasmoDB Total SNPs: 301
Non-coding: 207 | Synonymous: 77 | Nonsynonymous: 17 | Stop Codon: 0
Protein Length: 1018 | Molecular Weight (kDa): 122.106
UniProt ID(s): C0H4S1
PDB ID(s): None
Isoelectric Point: 9.57
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR018732 | Dpy-19/Dpy-19-like |
| InterPro | IPR030038 | C-mannosyltransferase Dpy-19 |
| PFam | PF10034 | Dpy-19/Dpy-19-like |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 29432542 | Apicomplexan C-Mannosyltransferases Modify Thrombospondin Type I-containingAdhesins of the TRAP Family. | Hoppe CM, Albuquerque-Wendt A, ..., Routier FH | 10.1093/glycob/cwy013 |
| 31559936 | A Plasmodium falciparum C-mannosyltransferase is dispensable for parasite asexualblood stage development. | Lopez-Gutierrez B, Cova M, Izquierdo L | 10.1017/S0031182019001380 |
| 35906227 | Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission. | Lopaticki S, McConville R, ..., Boddey JA | 10.1038/s41467-022-32076-8 |
| 31862733 | C-Mannosylation of Toxoplasma gondii proteins promotes attachment to host cellsand parasite virulence | Albuquerque-Wendt A, Jacot D, ..., Routier FH | 10.1074/jbc.RA119.010590 |