PF3D7_0806700

Genome location: Pf3D7_08_v3:353,841..362,906(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.76	0.66
Trophozoite	expressed	1.04	0.48
Schizont	expressed	0.37	0.78
Gametocyte	expressed	1.29	0.38

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0806700

Resistome Missense Mutations: D1110G

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.985 | MFS: -2.776 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZVL6

"Best" AlphaFill ligand hit: APC (alpha,beta-methyleneadenosine-5'-triphosphate, Local RMSD=10.63) with 6KCK (Global RMSD=23.62)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139185

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	72	38	113
disruptive	82	206	121	314
missense	44	159	110	267

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	31	122	77	122
disruptive	142	425	217	431
missense	67	322	182	345

PlasmoDB Total SNPs: 444

Non-coding: 103 | Synonymous: 188 | Nonsynonymous: 152 | Stop Codon: 1

Protein Information

Protein Length: 2572 | Molecular Weight (kDa): 307.601

UniProt ID(s): A0A143ZVL6

PDB ID(s): None

Isoelectric Point: 8.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A